{"id":8561,"date":"2015-05-15T20:38:26","date_gmt":"2015-05-15T20:38:26","guid":{"rendered":"https:\/\/taylormartino.com\/?p=8561"},"modified":"2019-07-10T21:03:23","modified_gmt":"2019-07-10T21:03:23","slug":"farxiga-invokamet-jardiance-fda-safety-warning","status":"publish","type":"post","link":"https:\/\/taylormartino.com\/farxiga-invokamet-jardiance-fda-safety-warning\/","title":{"rendered":"Farxiga \/ Invokamet \/ Jardiance: FDA Safety Warning"},"content":{"rendered":"\r\n<ul class=\"wp-block-gallery columns-1 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\r\n<li class=\"blocks-gallery-item\">\r\n<figure id=\"attachment_8564\" aria-describedby=\"caption-attachment-8564\" style=\"width: 800px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8564 \" src=\"https:\/\/taylormartino.com\/wp-content\/uploads\/2015\/05\/Farxiga-Invokamet-Jardiance-FDA-Safety-Warning-300x200.jpg\" alt=\"Farxiga \/ Invokamet \/ Jardiance: FDA Safety Warning\" width=\"800\" height=\"533\" data-id=\"7189\" data-link=\"https:\/\/taylormartino.com\/?attachment_id=7189\" srcset=\"https:\/\/taylormartino.com\/wp-content\/uploads\/2015\/05\/Farxiga-Invokamet-Jardiance-FDA-Safety-Warning-300x200.jpg 300w, https:\/\/taylormartino.com\/wp-content\/uploads\/2015\/05\/Farxiga-Invokamet-Jardiance-FDA-Safety-Warning-768x512.jpg 768w, https:\/\/taylormartino.com\/wp-content\/uploads\/2015\/05\/Farxiga-Invokamet-Jardiance-FDA-Safety-Warning.jpg 1000w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-8564\" class=\"wp-caption-text\">Farxiga \/ Invokamet \/ Jardiance: FDA Safety Warning<\/figcaption><\/figure>\r\n<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<span class=\"gdlr-core-space-shortcode\" style=\"margin-top: 30px ;\"  ><\/span>\r\n<p>FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood<\/p>\r\n<div id=\"collapseOne\" class=\"panel-collapse collapse in\">\r\n<div class=\"panel-body\">\r\n[ 05-15-2015 ]The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines canagliflozin, dapagliflozin, and empagliflozin may lead to ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones that may require hospitalization. We are continuing to investigate this safety issue and will determine whether changes are needed in the prescribing information for this class of drugs, called sodium-glucose cotransporter-2 (SGLT2) inhibitors.<\/p>\r\n<p>Patients should pay close attention for any signs of ketoacidosis and seek medical attention immediately if they experience symptoms such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. Do not stop or change your diabetes medicines without first talking to your prescriber. Health care professionals should evaluate for the presence of acidosis, including ketoacidosis, in patients experiencing these signs or symptoms; discontinue SGLT2 inhibitors if acidosis is confirmed; and take appropriate measures to correct the acidosis and monitor sugar levels.<\/p>\r\n<p>SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. These medicines are available as single-ingredient products and also in combination with other diabetes medicines such as metformin (see Table 1 below). The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.<\/p>\r\n<p>A search of the FDA Adverse Event Reporting System (FAERS) database identified 20 cases of acidosis reported as diabetic ketoacidosis (DKA), ketoacidosis, or ketosis in patients treated with SGLT2 inhibitors from March 2013 to June 6, 2014 (see Data Summary). All patients required emergency room visits or hospitalization to treat the ketoacidosis. Since June 2014, we have continued to receive additional FAERS reports for DKA and ketoacidosis in patients treated with SGLT2 inhibitors.<\/p>\r\n<p>DKA, a subset of ketoacidosis or ketosis in diabetic patients, is a type of acidosis that usually develops when insulin levels are too low or during prolonged fasting. DKA most commonly occurs in patients with type 1 diabetes and is usually accompanied by high blood sugar levels. The FAERS cases were not typical for DKA because most of the patients had type 2 diabetes and their blood sugar levels, when reported, were only slightly increased compared to typical cases of DKA. Factors identified in some reports as having potentially triggered the ketoacidosis included major illness, reduced food and fluid intake, and reduced insulin dose.<\/p>\r\n<p>We urge health care professionals and patients to report side effects involving SGLT2 inhibitors to the FDA MedWatch program, using the information in the \u201cContact FDA\u201d box at the bottom of the page.<\/p>\r\n<h4>Table 1. List of SGLT2 inhibitors<\/h4>\r\n<div class=\"table-responsive\">\r\n<table class=\"table table-bordered table-striped\" border=\"1\" summary=\"List of SGLT2 inhibitors\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\">\r\n<tbody>\r\n<tr>\r\n<th valign=\"top\">Brand name<\/th>\r\n<th valign=\"top\">Active ingredient(s)<\/th>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Invokana<\/td>\r\n<td valign=\"top\">canagliflozin<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Invokamet<\/td>\r\n<td valign=\"top\">canagliflozin and metformin<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Farxiga<\/td>\r\n<td valign=\"top\">dapagliflozin<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Xigduo XR<\/td>\r\n<td valign=\"top\">dapagliflozin and metformin extended-release<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Jardiance<\/td>\r\n<td valign=\"top\">empagliflozin<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\">Glyxambi<\/td>\r\n<td valign=\"top\">empagliflozin and linagliptin<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"panel panel-default\">\r\n<div class=\"panel-heading\">\r\n<h4 class=\"panel-title\"><a id=\"anch_27\" class=\"toggle collapsed\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm446845.htm#collapseThree\" target=\"_blank\" rel=\"noopener noreferrer\" data-parent=\"#accordion\" data-toggle=\"collapse\"><span style=\"color: #0066cc;\">Facts about Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors<\/span><\/a><\/h4>\r\n<\/div>\r\n<div id=\"collapseThree\" class=\"panel-collapse collapse\">\r\n<div class=\"panel-body\">\r\n<ul>\r\n<li>SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes.<\/li>\r\n<li>The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.<\/li>\r\n<li>Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin. They are available as single-ingredient products and also in combination with other diabetes medicines such as metformin (see Table 1 in the Safety Announcement section for a complete list).<\/li>\r\n<li>SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine.<\/li>\r\n<li>In addition to acidosis, other possible side effects of SGLT2 inhibitors include dehydration, kidney problems, low blood sugar when this class of medicines is combined with other prescription medicines used to treat diabetes, increased cholesterol in the blood, and yeast infections.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"panel panel-default\">\r\n<div class=\"panel-heading\">\r\n<h4 class=\"panel-title\"><a id=\"anch_28\" class=\"toggle collapsed\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm446845.htm#collapseFour\" target=\"_blank\" rel=\"noopener noreferrer\" data-parent=\"#accordion\" data-toggle=\"collapse\"><span style=\"color: #0066cc;\">More Info for\u00a0Patients<\/span><\/a><\/h4>\r\n<\/div>\r\n<div id=\"collapseFour\" class=\"panel-collapse collapse\">\r\n<div class=\"panel-body\">\r\n<ul>\r\n<li>Acidosis is when there is too much acid in the body. Diabetic ketoacidosis and ketoacidosis, serious conditions in which the body produces high levels of blood acids called ketones, have been reported in patients using the diabetes medicines known as sodium-glucose cotransporter-2 (SGLT2) inhibitors (see Table 1 in the Safety Announcement section for a complete list). Ketones can build up in the body if insulin levels are too low or during prolonged fasting.<\/li>\r\n<li>Pay close attention for any signs or symptoms of acidosis such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. Seek medical attention immediately if you experience any of these symptoms.<\/li>\r\n<li>Ketoacidosis associated with SGLT2 inhibitors may be present even if the blood sugar is not very high.<\/li>\r\n<li>The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.<\/li>\r\n<li>Do not stop or change your diabetes medicines without first talking to your health care professional. When untreated, diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease.<\/li>\r\n<li>Read the patient Medication Guide or Patient Package Insert you receive with your SGLT2 inhibitor prescription. They explain the benefits and risks associated with the use of the medicine. You may access Medication Guides by clicking on this <a id=\"anch_29\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm085729.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0066cc;\">link<\/span><\/a>.<\/li>\r\n<li>Talk to your health care professional if you have questions or concerns about SGLT2 inhibitors or any of your other diabetes medicines.<\/li>\r\n<li>Report side effects from SGLT2 inhibitors to the FDA MedWatch program, using the information in the &#8220;Contact FDA&#8221; box at the bottom of this page.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"panel panel-default\">\r\n<div class=\"panel-heading\">\r\n<h4 class=\"panel-title\"><a id=\"anch_30\" class=\"toggle collapsed\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm446845.htm#collapseFive\" target=\"_blank\" rel=\"noopener noreferrer\" data-parent=\"#accordion\" data-toggle=\"collapse\"><span style=\"color: #0066cc;\">More Info for Health Care Professionals<\/span><\/a><\/h4>\r\n<\/div>\r\n<div id=\"collapseFive\" class=\"panel-collapse collapse\">\r\n<div class=\"panel-body\">\r\n<ul>\r\n<li>Be aware that postmarketing cases show an association between sodium-glucose cotransporter-2 (SGLT2) inhibitor use and the development of a high anion gap metabolic acidosis accompanied by elevation in urine or serum ketones.<\/li>\r\n<li>Evaluate for the presence of acidosis, including ketoacidosis, in patients experiencing signs or symptoms of acidosis; discontinue SGLT2 inhibitors if acidosis is confirmed; and take appropriate measures to correct the acidosis and to monitor glucose levels.<\/li>\r\n<li>Supportive medical care should be instituted to treat and correct factors that may have precipitated or contributed to the metabolic acidosis.<\/li>\r\n<li>Inform patients and caregivers of the signs and symptoms of metabolic acidosis, such as tachypnea or hyperventilation, anorexia, abdominal pain, nausea, vomiting, lethargy, or mental status changes, and instruct them to seek medical attention immediately if they experience the signs or symptoms.<\/li>\r\n<li>Encourage patients to read the Medication Guide or Patient Package Insert they receive with their SGLT2 inhibitor prescriptions.<\/li>\r\n<li>SGLT2 inhibitors are not FDA-approved to treat patients with type 1 diabetes mellitus.<\/li>\r\n<li>The high anion gap metabolic acidosis accompanied by elevation in urine or serum ketones in the reported cases was not associated with the very high glucose levels that are typical for diabetic ketoacidosis.<\/li>\r\n<li>Potential diabetic ketoacidosis (DKA) triggering factors identified in some cases included acute illness (e.g., urinary tract infection, urosepsis, gastroenteritis, influenza, or trauma), reduced caloric or fluid intake, and reduced insulin dose.<\/li>\r\n<li>Potential factors contributing to the high anion gap metabolic acidosis identified in some cases included hypovolemia, acute renal failure, hypoxemia, reduced oral intake, and a history of alcohol use.<\/li>\r\n<li>Approximately half of the cases did not identify a typical DKA triggering factor or alternative explanation for the metabolic acidosis.<\/li>\r\n<li>In all cases, the patients required emergency room visits or hospitalization to treat the acidosis.<\/li>\r\n<li>Report adverse events involving SGLT2 inhibitors to the FDA MedWatch program, using the information in the &#8220;Contact FDA&#8221; box at the bottom of this page.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"panel panel-default\">\r\n<div class=\"panel-heading\">\r\n<h4 class=\"panel-title\"><a id=\"anch_31\" class=\"toggle collapsed\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm446845.htm#collapseSix\" target=\"_blank\" rel=\"noopener noreferrer\" data-parent=\"#accordion\" data-toggle=\"collapse\"><span style=\"color: #0066cc;\">Data Summary<\/span><\/a><\/h4>\r\n<\/div>\r\n<div id=\"collapseSix\" class=\"panel-collapse collapse\">\r\n<div class=\"panel-body\">\r\n<p>FDA searched the FDA Adverse Event Reporting System (FAERS) database from March 2013 (approval of the first drug in the class) through June 6, 2014, and identified 20 cases of diabetic ketoacidosis (DKA), ketoacidosis, or ketosis reported with the sodium-glucose cotransporter-2 (SGLT2) inhibitors. Type 2 diabetes mellitus was noted as the indication in most of the cases, type 1 diabetes mellitus was noted in a few cases, and some cases did not specify the indication.<\/p>\r\n<p>In all cases, a diagnosis of DKA or ketoacidosis was made by a health care professional, and hospitalization of the patients was required to treat the episode. A temporal association with SGLT2 inhibitor initiation was noted in all cases. The median time to onset of symptoms following initiation of drug therapy was 2 weeks (range 1 to 175 days). DKA case presentations were atypical in that glucose levels were only mildly elevated at less than 200 mg\/dL in some reports, while patients with type 1 diabetes who have DKA typically have glucose levels greater than 250 mg\/dL. In addition, DKA is not typically observed in patients with type 2 diabetes.<\/p>\r\n<p>In most cases, a high anion gap metabolic acidosis accompanied by elevated blood or urine ketones was reported. Potential DKA-triggering factors that were identified in some cases included acute illness or recent significant changes such as infection, urosepsis, trauma, reduced caloric or fluid intake, and reduced insulin dose. Potential factors, other than hypoinsulinemia, contributing to the development of a high anion gap metabolic acidosis identified in the cases included hypovolemia, acute renal impairment, hypoxemia, reduced oral intake, and a history of alcohol use. Half of cases did not identify a triggering factor for DKA.<\/p>\r\n<p>We are continuing to investigate this safety issue. Additional reports of DKA continue to be submitted to us, and we will determine whether changes are needed in the labeling for this class of drugs.<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<p style=\"margin: 1em 0px;\"><a id=\"anch_32\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm447209.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0066cc;\">en Espa\u00f1ol<\/span><\/a><\/p>\r\n<p style=\"margin: 1em 0px;\"><a id=\"anch_33\" href=\"http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/UCM446954.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0066cc;\">Drug Safety Communication<\/span><\/a> (PDF &#8211; 50KB)<\/p>\r\n<p><!--==== BEGIN Mainlist_Folio ====--><!--$if not isTrue(rsExists(folioNavSetName)) or isTrue(ssShowEditButton)$--><!--only do dynlist tool process if we have both a query and display -->Related Information<\/p>\r\n<div class=\"panel panel-default box\">\r\n<div class=\"panel-body\">\r\n<ul>\r\n<li><a id=\"anch_34\" href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm446852.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0066cc;\">Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors<\/span><\/a><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<p>Contact FDA<\/p>\r\n<div id=\"Contact_Us\" class=\"panel panel-default box contact-us\">\r\n<div class=\"panel-body\">\r\n<div class=\"row\">\r\n<div class=\"col-sm-6 col-md-12\">\r\n<div class=\"phone_number\" title=\"Primary Phone Number\"><b>For More Info<\/b><\/div>\r\n<div class=\"phone_number\" title=\"Alternative Phone Number\">855-543-DRUG (3784)<\/div>\r\n<div class=\"phone_number\" title=\"Alternative Phone Number\">and press 1<\/div>\r\n<div class=\"email_address\"><span class=\"email_address\"><span style=\"color: #0066cc;\"><a id=\"anch_35\" 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class=\"gdlr-core-space-shortcode\" style=\"margin-top: 40px ;\"  ><\/span>\r\n","protected":false},"excerpt":{"rendered":"<p>FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood [ 05-15-2015 ]The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines canagliflozin, dapagliflozin, and empagliflozin may lead to ketoacidosis, a serious condition where the body produces high levels of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":8564,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[95],"tags":[99,10,13,16],"class_list":["post-8561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-dangerous-product","tag-general-practice","tag-law","tag-personal-injury"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - 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